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Description

TLR4 enhances TGF-beta signaling and hepatic fibrosis

The histone H3K4 demethylase LSD1 has been investigated as a target in Ewing sarcoma and AML, where LSD1 inhibition induces differentiation of AML cells (2) and blocks fusion protein transcriptional targets in sarcoma (3)

( b ) Representative flow cytometry plots showing splenic M45 + virus specific CD8 T cells from chimeric mice infected with MCMV, vCD44BP (day 7 PI) or uninfected controls