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Beyond established anti-inflammatory and antioxidant properties (181, 182), urolithins directly suppress tumorigenesis via concerted modulation of key oncogenic pathwaysincluding AKT/WNK1 (183), p53/mdm2/Snail (184), p53/TIGAR (185), Wnt/-catenin (186), and PI3K/AKT/mTOR cascades (187, 188)culminating in cell cycle arrest and apoptosis across malignancies (183190)