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A., Torgerson, S., Hayashi, P., Ward, J

For IM ketorolac, studies have found no benefit to administering greater than 15 mg, such as in this 2021 paper published in the American Journal of Emergency Medicine (2)

Additionally, the clinical trial was terminated due to the occurrence of side effects, including impaired dark color adaptation [200, 202]

Mast cell activation and histamine release Mast cells are the primary drivers of injection site itching and redness

The interaction mechanism with host tissues is complex and hard to dissect at the molecular level, partly due to the lack of suitable animal models (Loukas and Prociv, 2001), and the roles of many bigger molecules, particularly proteins, are yet to be understood