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[DOI] [PubMed] [Google Scholar] 62.Sun X., Zhang T., Zhao Y., Cai E., Zhu H., Liu S

This effect is probably mediated by the MAPK/Erk1/2 pathway, whereby insulin stimulates the hypothalamus to secrete gonadotropin-releasing hormone (GnRH) ( 3.3 Advanced glycation end products AGEs can severely impair sperm function through multiple mechanisms

In addition, the amount of change in a biomarker protein can be determined by detecting post-translational modifications that can affect the expression or activity of the biomarker protein (e.g., the methylation state of the marker)

Furthermore, repeated oral administration of PDEVs has been shown not to alter physiological, biochemical, or behavioral parameters in experimental animals, and does not elicit local or systemic toxic reactions (Zhang et al., 2016)

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