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It ages, loses elasticity, and suffers from oxidative stress and environmental damage

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10.1007/978-1-59745-367-7_1 487 PrivalovP

14 Important differential diagnoses to consider include medication side effects (eg, methotrexate, chemotherapy, or antibiotics such as trimethoprim), and malabsorption due to an anatomic or autoimmune cause (pernicious anemia), as well as a primary bone marrow pathology such as myelodysplastic syndrome