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A.SachanM

Sood SK, Salzman MB, Johnson BJ, et al

10.1016/j.biopha.2022.114086 139 YangG.WangH.KangY.ZhuM

In LSDs, defective enzymes lead to the accumulation of toxic substances in the lysosomes, causing cell damage and degeneration of neural tissue

For instance, oral administration might be subject to first-pass metabolism in the liver, reducing the effective concentration of 5-Amino-1MQ compared to a direct subcutaneous injection