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The best way to see this is to compare space-filling models of methyl bromide and the more hindered carbon atoms in ethyl-, isopropyl-, and finally tert -butyl bromide (Figure 6.13)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Bakunina N., Pariante C.M., Zunszain P.A

The ctDNA fraction of the total ccfDNA depends on the disease setting and tumour spread and can range from 1% or below at diagnosis and/or in patients with localised disease, and up to 90% in patients with high-volume progressing metastases in castration-resistant prostate cancer [6,7,8]