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albicans (Wang et al., 2022)

doi: 10.1093/jn/138.9.1596 119

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The interaction among pro-inflammatory cytokines, glucocorticoid resistance, and HPA axis hyperactivity creates a feedback loop that perpetuates inflammation and compromises neural function, particularly in regions associated with mood and neurogenesis

Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition