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ESPGHAN score correctly diagnosed these children when additional points are given for the presence of peri-nuclear neutrophilic antibodies and cholangiographic abnormalities [29]

Conversely, Helional activates OR2J3 on A549 cells, triggering PI3K pathway activation, which leads to apoptosis and proliferation inhibition (72), highlighting the differential effects of ligands on the same receptor in different cell types

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