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Genetics in ankylosing spondylitis current state of the art and translation into clinical outcomes

Ferroptosis Ferroptosis, a form of iron-dependent cell death triggered by lipid peroxidation and accumulation of lipid-based reactive oxygen species [118,119,120], appears to be influenced by copper levels due to the redox-active properties of copper ions [121, 122]

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However, during cancer progression, the accumulation of inducible nitric oxide synthase positive (iNOS+) and CD11b+Gr1+ myeloid cells in the peritumoral region suppresses the contraction of tumor-draining collecting lymphatic vessels (117) ( Figure 1 ), which might diminish tumor antigen transportation and DC trafficking to the TDLNs, reducing the immune response (118)