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Description

B12 levels increased significantly more for pregnant than non-pregnant women when given an oral dose of 1,000 g (respective increase of 195 vs 117 pmol/l) or 500 g (respective increase of 147 vs 95 pmol/l), but not for 250 g (respective increase of 11 vs

Excessive doses may mask folate deficiency

2 Methyl-B12 is an essential cofactor in the one-carbon methylation cycle converting homocysteine to methionine, and in the course converting methyl-tetrahydrofolate back to tetrahydrofolate