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Jehl, J.R., and C.F

In cellular models of ALS the RNA processing gets severely impaired upon oxidative stress, in turn causing the mis-localization of TDP-43 and FUS ( Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation

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This historical context is important because it reveals that coffee enemas emerged not from systematic medical research, but from early alternative medicine theories that predate our current understanding of human physiology and detoxification

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