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The pia mater: a comprehensive review of literature

59, Jan

Reactive astrocytes have been shown to exert cytotoxicity, and as their activation intensifies, astrogliosis contributes to pathological features such as fibril accumulation, vascular damage, and BBB disruption (Liddelow et al., 2017

In regard to aging and cellular metabolism, the shortening of telomeres (TLs), complexes of deoxyribonucleic acid (DNA), can lead to the increased risk for the development of DM (267) and greater cell senescence with the loss metabolic homeostasis (178, 190, 268)

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