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Nrf2/ARE, as one of the important mechanisms to protect the liver from oxidative stress, can play a protective role in liver inflammation, ischemia/reperfusion, fibrosis and regeneration by inducing target genes ( 4 is a strong hepatoxic and prooxidant agent widely used to induce hepatotoxicity, and its animal model has been widely used to screen the anti-hepatotoxicity and/or hepatoprotective activity of drugs ( 4 causes a decrease in liver cells, in the activities of antioxidant enzymes and increases the protein carbonyl content, which is a protein oxidation product, at the oxidative stress biomarker MDA level ( in vivo , different doses of midazolam pretreatment were given to mice with acute liver injury induced by CCl 4

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4 The two faces of lipid peroxidation: Good or bad for human health

A P-value of less than 0.05 was considered significant

(2017) revealed that innate DNA sensing through cGAS governs the senescence program and the senescence-associated secretory phenotypes by detecting cytosolic chromatin fragments in senescent cells