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Immuno-oncology advances are propelled by three paradigm-shifting modalitiesimmune checkpoint disruption (anti-PD-1/CTLA-4) to reverse T-cell exhaustion, genetically engineered CAR-T cells targeting CD19/BCMA for tumor-specific cytotoxicity, and dendritic cell vaccines loaded with neoantigens to prime antigen-presenting cellswhich collectively overcome tumor immune evasion mechanisms, achieving durable remission rates exceeding 50% in refractory lymphomas (NCT02348216)

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