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Binding to antioxidant response elements (AREs) induces the transcription of genes regulated by AREs, which initiates the expression of genes encoding cytoprotective enzymes, such as antioxidative stress proteins, especially antioxidant enzymes ( Figure 2 The antioxidant response is also modulated by signaling pathways mediated by adenosine 5'-monophosphate-activated protein kinase (AMPK)

In a model of delayed-type hypersensitivity in mice, delta-9-THC (20 mg/kg) was reported to decrease tissue swelling and immune cell infiltration and decrease lymphocyte activation at the site of an antigen challenge in the footpad

Middleton J, Tyler JA

Aibani N, Rai R, Patel P, Cuddihy G, Wasan EK

Chandra V, Bhagyaraj E, Nanduri R, Ahuja N, Gupta P