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In a subgroup analysis of patients with HCC beyond the up-to-seven criteria, the median PFS times in the Atezo/Bev (n=134) and LEN (n=117) groups were 10.5 months (95% CI, 7.011.8) and 6.3 months (95% CI, 5.57.3), respectively (p=0.044)

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Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC et al (2012) Inhibition of the NF-B signaling pathway by the curcumin analog, 3,5-bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties