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While substantial neuronal loss has been consistently observed in AD, the precise mechanisms underlying neuronal elimination remain incompletely understood

Endogenous substrates such as hydrogen peroxide, glucose, and urea can be enzymatically catalyzed to generate concentration gradients for propulsion

Sources BUM-CHUN L

Kernicterus: Epidemiological Strategies for Its Prevention through Systems-Based Approaches

Therefore, the two crucial mechanisms are that the transduction of PAR polymer to mitochondrial and the transfer of AIF from mitochondrial to nucleus to degrade chromatin