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This heterogeneity reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition limits attempts to articulate an integrated perspective on bipolar disorder

The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [3336]

MTHFR gene mutations can also contribute to high homocysteine levels, as this gene affects folate metabolism

Anti-aging effect: Oxidative stress can accelerate the aging process and contribute to the appearance of signs of aging