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thus, we used as many intact individuals as possible as parents

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To further increase the ERG yield, we focused next on reinforcing the sulfur metabolic flux toward ERG biosynthesis, because this pathway was indicated to be the rate-limiting pathway in our previous study 26

Future work should include expert-driven evaluations of the identified KERs using the BH criteria, covering aspects such as biological plausibility, essentiality, empirical support (e.g., doseresponse and temporal patterns), and overall coherence across studies

When a research protocol shows a stalled response despite correct dosing, see why retatrutide may not be working