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BPC-157: 250 mcg subcutaneously, twice daily (morning and evening) Cryotherapy: Local ice application for 15-20 minutes every 2-3 hours during waking hours Timing: Apply cold therapy at least 30 minutes after BPC-157 injection to allow peptide absorption Rest the injured area as much as practically possible Reduce cold application frequency as acute swelling subsides

By the mid-2000s, the obesity pharmacotherapy field expected at least 5% placebo-subtracted weight loss for regulatory consideration, a threshold later codified in FDA's 2007 guidance for industry on developing obesity drugs

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