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Be Careful: Measure slowly and carefully to avoid errors

If you receive a lyophilized vial and do not plan to use it immediately, leaving it in powder form until needed preserves potency far longer than reconstituting and refrigerating

The simplistic and outdated two-hit hypothesis has been replaced by a multi-hit model that integrates various interconnected processes, as shown in Figure 2, where multiple factors act synergistically, encompassing lipotoxicity, gut dysfunction, altered gut-liver axis and innate immune activation, within the context of genetic and environmental factors (68)

published online, (25 April 2013)

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