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For musculoskeletal indications, the guideline is progressive load reintroduction starting no earlier than 6 to 8 weeks, with full training not before 3 months for significant tendon injuries regardless of how good the patient feels

4 Amylin is becoming a major partner pathway Amylin-based drugs such as cagrilintide and newer amylin receptor agonists are clinically important because amylin complements GLP-1 biology

The absence of clinical guidelines leaves surgeons navigating an evidence gap with potential medicolegal implications, particularly when patients undergo elective procedures where the acceptable tolerance for unmeasured risk is low