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Specifically, chondrocytes exposed to ferric ammonium citrate (FAC) exhibit increased expression of FTH1 and reduced levels of transferrin receptor 1 (TfR1) and hepcidin, whereas ferroportin (FPN1) expression remains unchanged ( 3.3.2 Fenton reactions and the bidirectional effects of iron homeostasis imbalance Free Fe + participates in the Fenton reaction, leading to the generation of hydroxyl radicals (OH), which represents a crucial step in initiating the lipid peroxidation chain reaction ( 3.3.3 Local iron homeostasis and the joint microenvironment Pathological changes such as increased vascular permeability or microbleeding in subchondral bone can also lead to local iron deposition

Platinum sensitivity of ovarian cancer cells does not influence their ability to induce M2-type macrophage polarization

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Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

10.3389/fcvm.2022.972603 146 SunN