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The aspartic protease ddi1 contributes to DNA-protein crosslink repair in yeast

These cytokines trigger the activation and recruitment of other immune cells, such as dendritic cells and macrophages, which drive abnormal keratinocyte proliferation and inflammatory reactions 44

The concentrations of IL-6, TNF-, and IL-1 in patients with LC were substantially elevated for prolonged periods (13)

In the context of tumor immune microenvironment, these findings suggest that circadian disruption potentially increases NETs formation, which has been shown to interfere with anti-tumor T and NK cell cytotoxicity 121

Oxidative stress in autoimmune rheumatic diseases