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10.1001/jamaophthalmol.2013.6636 JAMA Ophthalmol

The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial Chen J., et al

Material and methods Chemicals and experimental design Processed sulfur (97.9% inorganic sulfur) was purchased from Jungmin co., Ltd (Korea)

Background fluorescence was determined in each individual experiment with cells exposed to Triton (1%) and subtracted from all other values

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically