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The released mtDNA can activate cGASSTING signaling, creating a self-reinforcing loop where inflammation further impairs mitochondrial quality control, promotes additional mtDNA release, and accelerates neuronal degeneration

Biol Psychiatry 73(3):219224 Kruse LI, Kaiser C, DeWolf WE Jr, Frazee JS, Erickson RW, Ezekiel M, Ohlstein EH, Ruffolo RR Jr, Berkowitz BA (1986) Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine

10.1007/s12192-009-0159-0 28

DSM-Firmenich report (available at: Eaton DL, Williams DE, Coulombe RA (2025) Species differences in the biotransformation of aflatoxin B1: primary determinants of relative carcinogenic potency in different animal species

& Johannsen, M