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This scarcity of intracellular Gln hampers the synthesis of asparagine and proteins encoded by the mitochondrial genome, ultimately leading to ROS-induced apoptosis in tumor cells (45)

While candida is a normal resident of the gut, when it overgrows it can extend beyond the gut, through hyphae, which are branching filament-like structures that can penetrate gut tissue, contributing to intestinal permeability