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Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression

doi: 10.1002/ana.24384 50 FiguraM.FriedmanA

Under normoxic conditions, the alpha subunits of HIF are usually targeted for ubiquitination by the hydroxylation of prolyl particles and, later, are connected with von Hippel Lindau (VHL) proteins, leading to end-stage HIF alpha subunit degradation