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Preclinical studies show that moderate-intensity aerobic exercise, such as walking or cycling, can improve drug delivery to tumors, enhance immune cell infiltration, and potentiate treatment efficacy [83]

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Methylation imbalance impaired detoxification, neurotransmitter production, and DNA repair

123 In addition, the common pathogenic bacteria of COPD, nontypeable Haemophilus influenzae , contains cytoplasmic proteins that up-regulate human MUC5AC mucin transcription via a positive p38MAPK pathway and a negative phosphoinositide 3-kinase-Akt pathway