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Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis

The impact of metabolic activity on ER homeostasis is most evident form the association of ER stress with obesityparticularly in highly metabolically active tissues such as liver, pancreas, and adipose (Cnop, Foufelle, & Velloso, 2012)

*Correspondence: Jianmin Liang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

(2020) 10:E758

Such results could indicate that hepatic derived IGF-1 plays a crucial role in skeletal muscle insulin signalling and glucose uptake