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Description

Gaines et al., 2010

Stetler, C

10.1016/j.jpeds.2016.02.070 30

The synergy isn't additiveit's multiplicative, provided dosing timing prevents competitive inhibition at the cellular level

Analysis of datasets GSE96804 and GSE1009, for instance, identified 729RAAS inhibitor-related targets and 6,039 diabetic nephropathy-associated genes, with CTSC and PDE5A emerging as pivotal targets validated through Mendelian randomization analysis to have a causal relationship with the disease (Zhou et al., 2024)