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Together, these findings emphasize the therapeutic potential of targeting mtDNA-mediated innate immune activation, either through TLR9/cGASSTING pathway inhibition or mitochondria-targeted antioxidant therapy, to attenuate neuroinflammation and cognitive impairment in AD models

Some people should seek care sooner, including pregnant people, older adults, and anyone with existing medical conditions or on long-term medications

However, it is crucial to interpret these findings with caution

Tendon injuries are notorious for their prolonged recovery times, often causing significant discomfort and limiting mobility

As a proof of concept in treating oxidative stress-related diseases, the CuZnHis assemblies promote macrophage polarization from M1 to M2 phenotype and the expression of anti-inflammatory factors, and inhibit the periodontitis in male animal models