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Preclinical studies indicate that senescent cell burden is low in young rodents and increases with chronological age in several tissues (33, 34)

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Hydrochlorothiazide should be used cautiously in patients with renal disease such as severe renal impairment or renal failure

Cytokine measurement The serum was collected from mice after different treatments

The previously mentioned representative antioxidants, while playing an antioxidant role, are also nutrients needed by humans and can indirectly improve the state of malnutrition in the older population, further affecting immune function and playing a preventive role (65)