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Besides, a series of UA derivatives with different amino acid and dipeptide substitutions at the C-3 position, MDA-MB-231, are synthesized, and some of these derivatives (e.g., 4c, 7a, 10a) shows high cytotoxicity against triple-negative breast cancer (MDA-MB-231) cells, and inhibits cancer cell proliferation and migration, induces apoptosis and autophagy through various pathways [1079]

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It is worth noting that dysregulation of DNA methylation patterns has been linked to various brain disorders, including depression, anxiety, and cognitive decline (reviewed in: 14,15 )

Even before he hooked up with exploitation filmmaker and newly born-again zealot Ron Ormond, Pirkle was using props and skits to dramatize his sermons at Locust Grove Baptist Church in northern Mississippi