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The aberrant accumulation of A and hyperphosphorylated Tau proteins on mitochondria results in mitochondrial respiratory chain complex I activity, impaired mitochondrial membrane potential (MMP), and massive production of reactive oxygen species (ROS), which in turn affects mitochondrial function ( A number of studies have demonstrated that there are extensive mitochondrial abnormalities in the brains of AD patients and animal models (Swerdlow, 2018)

The serum levels of MDA were reduced significantly in the vitamin B12 group

1 Without treatment, exposure to a high dose of cyanide may result in death within minutes and may also cause central nervous system side effects, including altered mental status, parkinsonism, and personality changes

The K M values for H 2 O 2 of PRXII, 2-cys PRX and APX are quite similar, but the turnover rates of both types of PRX are significantly lower

The majority of reported multitarget effects pertain to the indirect cellular associations and suggests adaptive cellular responses instead of direct molecular target interaction