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doi: 10.2174/0115680096369817250407164352 182 KamilaSDey KoushikKChattopadhyayA

Laboratory investigation

CHAC1 is a key regulator of cellular stress responses, particularly oxidative stress, apoptosis, and ferroptosis, and it plays a central role in the pathogenesis of a wide range of non-malignant diseases

We intranasally inoculated 10-week-old male Syrian hamsters with the wild-type SARS-CoV-2 strain, the same as the strain found in patients recruited in this study