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Together, they also help protect brain cells from damage

Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] (Li and Dou, 2000), cyclin-dependent kinase inhibitor 1A [CDKN1A/p21] (Pagano et al., 1995), and tumor protein p53 [TP53] (Lopes et al., 1997)), which are responsible for cell growth inhibition or cell death induction

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