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The ability of cells to respond to this threat by the up regulation of GSH biosynthesis provides an intricate balance of reducing to oxidizing equivalents, allowing the redox homeostasis in the cell to be maintained

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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells