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This was partially attributed to different hepatic gene variants and expression levels (i.e., CETP, hepatic lipase, LPL, and PON1) between these two ethnicities (159, 160)

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Akt phosphorylation, which demonstrates PAM activation, occurs in 50% to 70% of NSCLCs and 30% to 66% of head and neck squamous cell carcinomas (HNSCCs) [81, 82]

This helps adjust the treatment if needed

In clinical trials, dose escalation protocols were used to minimize gastrointestinal side effects, starting from lower doses and titrating up to the 10mg maintenance dose over several weeks