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Nature 387 (6630), 296299

As a result, range of motion decreases even more

Cyclosporine A is a calcineurin inhibitor that modulates hair growth by prolonging the anagen phase, activating inactive melanocytes, and blocking catagen

The nanoreactors can catalyze the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) in hypoxic cancer cells

Translation: it calms mast cells, dials down the inflammatory cascade in skin and gut, and reduces the kind of low-grade irritation that drives redness, flares, and that "my skin reacts to everything" pattern