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Studies using skin fibroblasts derived from such Fabry patient biopsies showed a reduced respiratory chain enzyme activity, along with a reduction of energy-rich phosphates AMP, ADP and CP, indicating an impaired mitochondrial energy supply and that this can play a role in the pathogenesis of Fabry disease through a proposed change in the properties of the mitochondria membrane [38], further implicating the mitochondrial dysfunction as part of the symptoms

Why they work together: Argireline reduces expression lines (Botox-like effect) Retinol addresses overall skin texture and collagen Different mechanisms = complementary results Application strategy: Morning: Argireline serum (targets expression lines during day) Evening: Retinol Don't mix in same application (pH differences may reduce effectiveness) Syn-Coll (Palmitoyl Tripeptide-5) Compatibility: Excellent

10.1002/prot.26450 119 TabasI.RonD

qtot 0.266 9 OG311 1 ful O9 9 -0.554 15.9994

It is also proposed that aromatic amino acids, such as tryptophan, which are sensitive to oxidation, can be attacked by ROS, such as OH radicals or atomic oxygen (Tolouie et al