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Recently, Yang et al

As NEM can react and thus consume partial thiols, less amount of thiol is available for TPE-DCV to react

Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

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To directly examine the levels of H1 Asn76 and Asn77 deamidation to aspartic acid (H1(N76D/N77D)), we generated a site-specific antibody targeting H1(N76D/N77D) (Extended Data Fig