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In participants receiving coronary artery bypass grafting, 1215 days of oral trimetazidine (60 mg/day) significantly reduced IL-6 levels compared to placebo treatment at baseline, 5 mins after aortic unclamping, 12 and 24 h after surgery [164]

Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

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