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Sex-based metabolic variationsuch as in lipid metabolism, oxidative stress response, or amino acid turnovermay influence liver pathology and could, in principle, affect pharmacokinetics or therapeutic outcomes, including responses to praziquantel

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However, double-blind randomized clinical trials directed by Charles Moertel of the Mayo Clinic failed to show any positive effects of high dose vitamin C in cancer patients, as reported in two papers in the journal of New England Journal of Medicine

The SD rats were maintained in light-controlled facilities with access to water and food ad libitum throughout the study, at ambient temperature (25 C)