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MOTS-c expression is lower in senescent human fibroblast cells induced by replication stress [71]

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4), however, another study demonstrated that NF-B signaling pathway activation could reduce the expression of the crucial ferroptosis factors such as heme oxygenase 1 (HMOX1) and GPX4, which ultimately promoted oxidative stress and ferroptosis in cerebrovascular disease [93]

The initiation phase refers to the ROS-induced upregulation of NLRP3, caspase-1, IL-1, and IL-18 in EC

The key functional variant, a short/long repeat polymorphism (5-HTTLPR), influences the expression level of the transporter