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In non-obese diabetic (NOD) strain, supplementation of microbial metabolites acetate and butyrate provided protection against type 1 diabetes by enhancing gut integrity, decreasing diabetogenic cytokines, inhibiting autoreactive T cell, and inducing Treg functions (116)

doi: 10.1016/j.vph.2015.03.005 48 InoueKSakanoNOginoKSatoYWangDHKuboMet al

Patchy hair loss with well-defined borders suggests alopecia areata, an autoimmune condition that requires different treatment than telogen effluvium

The polyphosphate kinase gene ppk2 is required for Mycobacterium tuberculosis inorganic polyphosphate regulation and virulence

Early reports suggest its well-tolerated, but long-term safety is still being evaluated