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The clinical research industry has become more challenging in recent years for a variety of reasons including greater regulatory scrutiny, increasing complexity of trials and the unpredictability of the duration and success of individual projects

Cao X, Li X, Li J et al (2018) Quantitative determination of carcinogenic mycotoxins in human and animal biological matrices and animal-derived foods using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods

Although existing evidence supports the potential of vitamin D in the prevention and management of DM, key parameters such as optimal supplementation dosage, timing of intervention, and the development of individualized therapeutic strategies remain to be fully defined

Regarding direction (ii), the clinically approved PARPi olaparib, which induces synthetic lethality in BRCA-mutated or HRD tumor cells, has been shown to promote cellular senescence through DNA damage accumulation, senescence marker upregulation, and irreversible cell cycle arrest

Extracellular Proteases in Atherosclerosis and Restenosis