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Jew, S.-s

T., Chahine, E

Building upon this foundation, we further evaluate novel therapeutic strategies targeting this network, particularly the feasibility of enhancing treatment efficacy through combined blockade of hormonal signaling and oxidative damage

Moreover, thiol reducing molecules like glutathione and specific isoforms of thiols reductases, thioredoxins and glutaredoxins were found in different nuclear subcompartments, further supporting that thiol-dependent systems are active in the nucleus

Experiments in animals have shown that targeting of CD44 by antibodies, antisense oligonucleotides, and CD44-soluble proteins markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential of anti-CD44 agents