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Structural prediction by Alphafold 2 (AF2) 43 and AF3 44 revealed a short stretch with weak helical potential (P345-Q361), called Axin LIR (Fig

In xenograft pulmonary metastasis models, knockdown of IGF2BP3 in MDA-MB-231-Edr and MDA-MB-468-Edr cells reduced lung metastasis, whereas PLSCR1 overexpression reinstated metastatic capacity (Fig

Although current evidence supports a sophisticated mechanistic framework linking lactate-mediated hepcidin induction to ferroptosis, the tissue- and cell-type-specific effects of elevated lactate levels induced by diverse physiological and pathophysiological processes on iron homeostasis and ferroptosis throughout the body warrant further investigation

Berberine protects secondary injury in mice with traumatic brain injury through anti-oxidative and anti-inflammatory modulation

Hydrocodone and acetaminophen are known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function